Dr.V.M.Palaniappan, Ph.D.

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With best wishes and thanks,
Dr. Palani, Ph.D.




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Wednesday, November 13, 2013

CRITICAL EVALUATION OF CERTAIN STUDIES THAT FOUND CALCIUM SUPPLEMENTS MAY REDUCE

CRITICAL EVALUATION OF CERTAIN STUDIES THAT FOUND

CALCIUM SUPPLEMENTS MAY REDUCE

THE INCIDENCE OF COLO-RECTAL CANCERS.
 
(© 13 November, 2013: Dr.V.M.Palaniappan, Ph.D.)

Of late, it has become fashionable for manufacturers of food and drinks to claim that their products contain ABUNDANT CALCIUM.

Now-a-days, even a child knows that he/she has to take plenty  (?)of calcium if his/her bones, teeth, nails, and the entire body are to grow well, and remain healthy.   

As a result, almost without exception, ALL the drinks (beverages, orange juice), whether that be for children or for adults, are made rich by the addition of calcium.  

Where possible, the food manufacturers too do likewise (e.g., biscuits, corn flakes, etc.).

They convince us with the so-called scientific evidences. Daily minimum requirement of calcium is often used as a selling point.

In this process, both the manufacturers and the consumers appear to be overlooking TWO important aspects.

(1)   Their particular food item may meet certain percentage of the daily calcium requirement of a person.

What happens if the person takes double or triple servings of THAT product?

What would happen if THAT person consumes several other products that may contain ‘plenty’ of calcium, but to the level suggested by the Daily Minimum Requirement program?

Will they not add up to ENORMOUS quantities?

(2)   The universal truth is “Anything in EXCESS will be dangerous!”

*    *    *    *    *    *
Well, what would happen if a person consumes far too much of calcium?

According to Arabic Health Encyclopedia (2013: His Majesty King Abdullah Bin Abdulaziz (http://www.kaahe.org/health/en/334-calcium/334-6-calcium-calcium-toxicity.html)

Getting too much calcium can cause constipation. It might also interfere with the body's ability to absorb iron and zinc.
In adults, too much calcium from dietary supplements might increase the risk of kidney stones.

Although I am not too sure of the constipation aspect, I fully subscribe to the above statement.

In fact, there are a few more problems as well.

According to Wikipedia: http://en.wikipedia.org/wiki/Calcium (Oct., 2013):
...  movement of the calcium ion Ca2+ into and out of the cytoplasm functions as a signal for many cellular processes. As a major material used in mineralization of bone, teeth and shells...

MY OWN FINDINGS (Palaniappan, 1998-2013: 13 books):
1.      In the first place, calcium that goes into the body through natural food products and drinks, even if they happen to be rich in it, may not do much harm, provided the person voids adequate urine on a daily basis.

2.      Calcium supplementations would harm well-urinating people to a minor extent

3.      Even natural food and drinks would harm the under-urinating people.

4.      If under-urinating people take calcium supplements, they would end up with major diseases, such as type-2 diabetes, kidney stones, hypothyroidism, heart blockages, brain tumours, cancers, and the like.

5.  Likewise, if people whose faecal matter is SLIMY all the time (due to the intake of very high fibre or eating over-ripe fruits such as papaya, and the like), and if they take calcium supplements, the situation can become WORSE.

6.      It is true that excessive calcium, being highly alkaline, suppresses the utilization of iron from food, thus can cause iron-deficiency anaemia.

7.      Excessive calcium in the body makes a person dull-headed and lazy, owing to the above-indicated iron shortage.  Memory failure becomes a common complaint.

8.      It is true that excessive calcium within the body results in kidney stones, thickening of blood vessels, and also the heart blockages.

9.      Excessive calcium with adequate Vitamin-D (either from sunshine or from enriched consumables) gives rise extra bone growth, such as SPURS, or even to start off Chondosarcoma (cancer in the long bone).

10.      Apart from all the above, EXCESSIVE calcium enters into cells, and ENLARGES THEM,  resulting in the enlargement of the entire organ: e.g., Prostate Gland.

(I have observed this problem in nearly all those who consume excessive SOUPS: e.g., 14 bowls of any soup, every week.)

(After all, soups are  extracts of all water-soluble substances from vegetables or meats / bones, particularly the calcium.)

11.  Continued accumulation of such excessive calcium within the cells makes the cells HEAVIER as well. Collectively, the body becomes overweight / obese.

12  Such accumulations in the thyroid gland gives hypothyroidism.

13.  Too much of calcium gives early menopause to women.

14.  AGAIN, TOO MUCH OF THIS WILL GIVE OSTEOPROSIS IN MENOPAUSAL WOMEN. (Calcium deficiency does NOT give osteoporosis to women, instead, the brain sheds of the excess – I will discuss this elsewhere, again). (See Palaniappan, 2012: Menses, Menopause, and Osteoporosis”.)

15.  Too much of calcium increases the SIZE of the sperms, and reduces number of sperms and sperm motility in the seminal fluid.

16.  Far too much of calcium within the body (in the cells of the soft tissues, of course) gives rise to lumps / benign structures initially, which, upon further accumulation,  turn into cancers (See Palaniappan, 2010: Cancer: Causes, Cure and Prevention).

17.  Excessive calcium in the lymph ducts give rise to cancer there.

18.  Excessive calcium in the blood gives rise to blood cancer.

19.  Excessive calcium in the intercellular spaces in the brain of those people who sleep without a pillow (or positioning the head at a lesser level than rest of the body), gives rise to brain tumour.

20.  The same in the colo-rectal region gives rise to colo-rectal cancer, and so on.

At this, some of you may want to refer to a recent study that said that increased calcium intake has reduced the chances of colo-rectal cancer occurrence.

Some studies have reported that calcium intake may prevent colo-rectal cancer.

The following papers have relevance to this finding:

1.    Weingarten MA, Zalmanovici A, Yaphe J (2005). Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. In Weingarten, Michael Asher. "Dietary calcium supplementation for preventing colorectal cancer, adenomatous polyps and calcium metabolisism disorder".Cochrane database of systematic reviews (Online) (3): CD003548. doi:10.1002/14651858.CD003548.pub3.PMID 16034903.

2.    Baron JA, Beach M, Mandel JS (1999). "Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group". N. Engl. J. Med. 340 (2): 101–7.doi:10.1056/NEJM199901143400204PMID 9887161.

3.     Bonithon-Kopp C, Kronborg O, Giacosa A, Räth U, Faivre J (2000). "Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group"Lancet356 (9238): 1300–6. doi:10.1016/S0140-6736(00)02813-0.PMID 11073017.

After reading the above articles, you may want to counter-argue with me.

The above end-result should be true!  

I do not deny that.

That is, calcium supplementations could have reduced the incidence of colo-rectal cancer.

Let ME explain how the phenomenon could have occurred in this case.

I have established earlier (Palaniappan, 2010: Cancer: Causes, Cure and Prevention) that the glandular cells called adenomatous cells that make up the lining of the intestinal tract (at the colo-rectal region, in particular) absorbs ANY FREE CALCIUM AVAILABLE there.

About one-third of the calcium present in the food (especially the vegetable matter) eaten does not get absorbed, and is thrown out of the body as part of the faeces. The brain does this kind of management job.

If a person eats food that contains FAR TOO MUCH of FIBRES (e.g., as in most of the over-ripe fruits, such as mangos), or over-ripe papaya, and the like, the faces becomes SLIMY and ACIDIFIED by faecal bacteria.

When the faeces turns ACIDIC, hitherto unutilised / undigested / unabsorbed calcium present in the faeces in a ready state for defecation at the colo-rectal area (such as Calcium oxalate, for example) becomes FREED from the bound or locked-up state.

This freely available calcium gets absorbed by the glandular cells at the lining of the colo/rectal region, and gives rise to CANCER THERE.

The above being the case, IF A PERSON TAKES CALCIUM SUPPLEMENTATIONS AT THIS POINT, THAT WILL NEUTRALISE THE ACIDITY CREATED BY THE FAECAL BACTERIA.

When the ACID faeces turn ALKALINE (because of the fresh oral intake of calcium), the slimy faeces would get consolidated and turn to be a solid and shapely structure, thus preventing the release of the locked-up calcium as a free substance.

Thus, the availability of calcium TO THE ADENOMA CELLS AT THE COLO-RECTAL REGION WILL GET DRASTICALLY REDUCED, or stopped nearly totally.

As a result of reduced calcium accumulation, naturally, cancer would NOT occur at the colo-rectal region.

This is how the research study must have yielded a significant reduction in the rate of colo-rectal cancers.

At this, you may want to ask me another question:

If I said that it is excessive calcium that gives rise to cancer, how come that the calcium supplementation in these studies have actually lessened the incidences.

The following answer should justify this questioning:

If calcium is absorbed and retained in the cells present in the colo-rectal area, then, cancer would develop there.

In the case of calcium supplement intake, that calcium gets absorbed at a MUCH HIGHER LEVEL IN THE INTESTINAL TRACT (and not at the colon), enters into the blood stream, (and the excesses may get expelled into the lymph fluid as regulated by the calcitonin, since the lymph network being the drainage system to contain all the unwanted substances).

The calcium that had entered into the blood (or lymph) tends to get distributed to ALL parts of the body.

If Vitamin-D is available at that moment, this calcium excess would get fixed in the bones, and may even turn into SPURS.

If and when such a bone-fixation occurs, naturally for want of calcium excess, cancer will not occur at the colo-rectal region. Even the chances of cancer development in other parts of the body would become much less.

This will form my explanation/ interpretation for the findings reported in the following paper:

      Lappe, JM; Travers-Gustafson, D; Davies, KM; Recker, RR; Heaney, RP (2007). "Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial"The American journal of clinical nutrition 85 (6): 1586–91. PMID 17556697.

In the absence of Vitamin-D, the calcium from the blood (or lymph) may end up in ANY of the SOFT tissues in the body (e.g., breast, prostate gland, liver, pancreas, or any such organ).

If such excess calcium from the supplements get distributed evenly into other parts of the body, naturally, COLON or RECTAL region TOO would receive only a small, relatively insignificant share of the calcium excess.

Being in such a small quantity, the calcium in the colo-rectal region may not be enough to form a cancer there.

HENCE, THE ABOVE STUDIES HAD YIELDED A SIGNIFICANT REDUCTION IN THE COLO-RECTAL CANCER INCIDENCE.

If the above researchers monitored carefully the exact* body weight of the samples (the people who were used for the testing), they would have almost certainly noticed, an OVERALL INCREASE in the body weight of those people – due to the addition of the calcium excesses in the cells of various organs in the body.

(* Ref: How to take EXACT body weight: The weighing should be done without clothes, AFTER toileting, after voiding urine, before breakfast, all the time - i.e., daily. Only then, any two readings will become comparable.)

DO YOU KNOW WHY PEOPLE OFTEN DEVELOP CANCERS AT THE COLO-RECTAL REGION, AND NOT IN THE UPPER PARTS* OF THE SMALLER INTESTINES?

It is because, although calcium gets absorbed in any part of the small / large intestine, that calcium does NOT stay accumulated in the cells present at that location.

On absorption, such calcium is simply passed on to the liver for further distribution and use.

Whereas, it is in the colo-rectal region the faeces stays (for much longer duration) with unutilised calcium, and that contributes to cancer development  when the faeces turns acidic, as described earlier.

(* During daytime, the food keeps on moving in the smaller intestine.  However, if a person constantly and habitually eats very late night dinner, say after 10 or 11 p.m., the food would get stagnated in the upper parts of the intestinal tract, owing to the cessation of the peristalsis action.  

The peristalsis that resumes the next morning would push the food further.

Such over-night stagnation enhances the absorption of calcium by lining cells in the stomach itself to yield stomach or pancreatic cancer.

This does not seem to occur in early diners)

This would form one additional evidence to prove my point that it is calcium (from the acidified faecal matter) that gives rise to colo-rectal cancer, and not any other ‘magic’ substance or anomalous cell.

MY FINAL CONCLUSION IS THAT, IT IS CALCIUM EXCESS THAT GIVES RISE TO CANCER, NO MATTER WHAT PART OF THE BODY IT DEVELOPS, AND, THERE IS NO SUCH THING AS “CANCER CELLS”.

On this, you may want to question me as why and how the chemotherapy and/or radiations heal  some of the cancers in people.

I will write an appropriate and acceptable answer to this question in my next posting.

It is so because, I do not want to make this article too lengthy to read.

I sincerely hope that I have given an excellent answer to some of the disturbing questions that are faced by the mainstream medical professionals, particularly the oncologists.

Now, it is up to the World Health Organisation (WHO) and related research-oriented organisations to evaluate my findings with some amount of open-mindedness, for the benefit of mankind.

Well, friends, I sincerely thank you for reading such a hard-going critical analysis of the subject.

With best wishes and thanks.

Dr. Niappan, Ph.D.

(Dr. V.M. Palaniappan)
(Former short-name being “Dr. Palani").